To investigate the effect of dexmedetomidine on sleep after orthopedic surgery and its mechanism based on intestinal flora metabolism

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400085064

Enrollment

Unknown

Registered

2024-05-30

Start date

2024-06-01

Completion date

Unknown

Last updated

2024-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sleep disorder

Interventions

Case series:NA

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: ? Hospitalized patients undergoing hip/knee replacement; Age =18 years old;? Patients hospitalized after multiple operations were included as separate samples for each operation.

Exclusion criteria

Exclusion criteria: ? Take antibiotics for more than 3 days within 3 months before surgery;? Patients who regularly take sleep AIDS throughout the perioperative period;Take probiotics and/or prebiotics within 1 year prior to or during the study;? cases of intraoperative death;?) Diarrhea within 1 month after the study or during the study;? History of mental disorders.

Design outcomes

Primary

Measure	Time frame
Sleep monitoring indexes on the first night after surgery;Sleep monitoring indexes of patients on the second night after surgery;Changes of metabolites of intestinal flora before and after operation;	—

Secondary

Measure	Time frame
PSQI scale, NRS scale and QoR-15 scale were used to evaluate sleep, pain and recovery one month after surgery.;	—

Countries

China

Contacts

Public ContactWei Xiongli

Liuzhou Workers Hospital, Guangxi

270612145@qq.com+86 177 7632 0723

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026