Immunosuppression with respiratory failure
Conditions
Interventions
Immunosuppression with respiratory failure group:none
Sponsors
Peking University People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients over 18 years of age and immunosuppressed (solid or hematological malignancies, solid organ transplants, long-term or high-dose [=1mg/kg/ day] steroid therapy, other immunosuppressive therapy or solid tumor chemotherapy, HIV infection), At the same time, acute hypoxic respiratory failure is determined by the clinician to require nasal high-flow oxygen therapy (Diagnosis of hypoxic respiratory failure depends on blood gas analysis: Under the conditions of sea level, resting state and breathing air, Arterial partial pressure of oxygen (PaO2) <60mmHg. Arterial carbon dioxide partial pressure (PaCO2) < 50mmHg.
Exclusion criteria
Exclusion criteria: Exclusion criteria: (1) hypercapnia (PaCO2= 50mmHg) and/or ventilation dysfunction (pH<7.25); (2) Respiratory and cardiac arrest, requiring immediate tracheal intubation; (3) Patients with weak spontaneous breathing and coma; (4) Very severe hypoxic respiratory failure (PaO2/FiO2<60mmHg); (5) Patients who changed to HFNC sequential therapy after tracheal intubation invasive ventilation treatment improved; (6) Serious non-cooperation, refusal to use HFNC treatment; (7) Patients who received HFNC treatment for less than 24 hours and their condition changed to non-invasive positive pressure ventilation or tracheal intubation mechanical ventilation; (8) Refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ROX index;mROX index;VOX index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percutaneous oxygen saturation; | — |
Countries
China
Contacts
Public ContactYangHuan
Peking University People's Hospital
Outcome results
None listed