Esophagogastric junction adenocarcinoma
Conditions
Interventions
Research Group :The reconstruction of the digestive tract requires the use of instruments for anastomosis and barbed wire to close the joint opening of the esophagus, stomach, or esophagus and jejunum
Sponsors
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Informed consent of patients and their families 2) 18 years old < age < 80 years old 3) Preoperative gastroscopic pathological biopsy showed histologically confirmed adenocarcinoma (papillary adenocarcinoma, tubular adenocarcinoma, mucinous adenocarcinoma, sig-ring cell carcinoma, poorly differentiated adenocarcinoma, mixed type adenocarcinoma); 4) After gastroscopy, abdominal CT or upper gastrointestinal angiography, the tumor location was consistent with the definition of Siewert type II esophagogastric junction adenocarcinoma in the "Chinese expert Consensus", that is, the tumor center was within the interval of 1cm above and 2cm below the anatomical junction of esophagus and stomach, and crossed or touched the esophagogastric junction. 5) Abdominal enhanced CT/MRI with clinical staging of cT1b-4aN0-3M0 (according to AJCC-8thTNM tumor staging); 6) Karnofsky physical condition score =70%; Or ECOG score =2 points; 7) Preoperative ASA score I-III
Exclusion criteria
Exclusion criteria: 1) Middle and upper mediastinal lymph node metastasis was clinically diagnosed; 2) Pregnant or nursing women; 3) Have a history of uncontrolled seizures, central nervous system diseases or mental disorders; 4) Clinically serious heart disease, such as symptomatic coronary heart disease, NYHA Class II or worse congestive heart failure, or severe arrhythmia requiring medical intervention, or a history of myocardial infarction within the last 6 months. Or have a history of cerebral infarction or cerebral hemorrhage within the last 6 months; 5) Moderate or severe renal injury [creatinine clearance rate equal to or less than 50ml/min (calculated according to Cockroft and Gault equations)], or serum creatinine>upper normal limit (ULN); 6) Emergency surgery due to tumor emergencies (bleeding, perforation, obstruction); 7) Patients who are unable to perform instrument matching;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of anastomotic complications.; | — |
Secondary
| Measure | Time frame |
|---|---|
| 30-day postoperative complication rates;surgical time ;Early postoperative recovery process;Incidence of anastomotic leakage ; | — |
Countries
China
Contacts
Public ContactWei Wang
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed