depression
Conditions
Interventions
Low-dose ECT group:Low-dose ECT
ECTgroup:Standard-dose ECT
Sponsors
Huilongguan Medical Hospital of Peking University
Eligibility
Sex/Gender
All
Age
13 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Subjects were between 13 and 18 years old (including borderline values), male and female were not limited; 2. Meet the DSM-5 diagnostic criteria for depressive disorders, with a score of >=17 on the 17-item Hamilton Depression Scale (HAMD-17); 3. Right-handed, no physical therapies( transcranial magnetic stimulation, electroconvulsive therapy, transcranial direct current stimulation, etc.), psychological therapies (cognitive-behavioral therapies, etc.) affecting cognitive function in the last 6 months; 4. No contraindication to ECT; 5. All subjects participated in the study voluntarily and signed a written informed consent form by themselves or their legal representatives before enrollment.
Exclusion criteria
Exclusion criteria: 1. Those who are currently or have previously suffered from bipolar I or II disorder, schizophrenia or other psychotic disorders, schizoaffective disorder, autism or autism spectrum disorders, borderline personality disorder, antisocial personality disorder, body dysmorphic disorder, eating disorders, hoarding disorders, and Tourette's disorder according to DSM-5 criteria; 2. Patients who have received physical (e.g., transcranial magnetic stimulation, electroconvulsive shock, transcranial direct current stimulation, etc.), psychotherapy (cognitive-behavioral therapy, etc.), etc., affecting cognitive function, or those who have received psychosurgery or deep brain stimulation (DBS); 3. History of severe cardiovascular, respiratory, and immune system diseases, suffering from other physical diseases that affect cognitive function, and those who cannot tolerate medication. Personal, family history of epilepsy or previous history of brain surgery or head injury (loss of consciousness for more than 30 minutes); 4. Major craniocerebral injury, cochlear implantation or the presence of metal implants in the body (including braces, pacemakers, metal dentures, implanted plates and nails after trauma surgery). Severe cervical spondylosis including cervical spinal stenosis and cervical instability; 5. Those with pervasive developmental disorders (autism spectrum disorders), severe cognitive dysfunction, verbal communication disorders, or those who are unable to cooperate in completing cognitive testing and electroconvulsive therapy; 6. Those who are addicted to or abuse psychoactive substances such as alcohol, caffeine and morphine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMA-17; | — |
Secondary
| Measure | Time frame |
|---|---|
| MCCB;Structrual and functional magnetic resonance image ;SIOSS;GAD-7;BPRS-4;ASLEC;CGI-S;BPFS-C;CBF-PI-B; | — |
Countries
China
Contacts
Public ContactZhiren Wang/Ruonan Du
Huilongguan Medical Hospital of Peking University
Outcome results
None listed