cognitive frailty
Conditions
Interventions
cognitive frailty:transcranial magnetic stimulation
cognitive frailty with subjective tinnitus:transcranial magnetic stimulation
cognitive frailty:sham transcranial magnetic stimulation
cognitive frailty with subjective tinnitus:sham transcranial magnetic stimulation
Sponsors
Huadong hospital, Shanghai medical college, Fudan university
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Aged 60 years and older, and no more than 90 years old community dwelling adults. 2. Old adults with cognitive frailty, cognitive frailty combined with subjective tinnitus. 3. Idividuals can comply with the test protocol and with informed consent form signed by family members or guardians.
Exclusion criteria
Exclusion criteria: 1. With serious neurological/mental diseases, dementia, severe depression and anxiety; Autoimmune diseases, vital organ failure, terminal disease. 2. Medicine have significant effect on cognition 3.Disability (dependence, profound hearing loss, blindness) 4. Actue inflammational diseases, brain trauma, and stroke 5. scarce of informed consent 6. Scarce of basic personal information 7. Can not conduct some important tests 8. Serious alcohol or drug abuse 9. Participate other clinical study simultaneously 10. Other issues that researchers believe that those who cannot be included in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cognitive performance;tinnitus;cognitive frailty;psychological performance ;hearing function; | — |
Secondary
| Measure | Time frame |
|---|---|
| quality of life;Activities of Daily Living;Instrumental Activities of Daily Living (IADL);3-T Magnetic Resonance Imaging (MRI) and functional MRI;neurotransmitter;adverse event; | — |
Countries
China
Contacts
Public ContactZhijun Bao
Huadong hospital, fudan university
Outcome results
None listed