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Clinical effects of photodynamic therapy with Ondapench photosensitive antibacterial powder as photosensitiser compared with mupirocin ointment in the treatment of bacterial skin infections

Clinical effects of photodynamic therapy with Ondapench photosensitive antibacterial powder as photosensitiser compared with mupirocin ointment in the treatment of bacterial skin infections

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400085012
Enrollment
Unknown
Registered
2024-05-29
Start date
2024-06-01
Completion date
Unknown
Last updated
2024-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bacterial skin infection

Interventions

Experimental group:Red light irradiation + Ondapench photosensitive antibacterial powder
Control group:Red light irradiation + Mupirocin ointment

Sponsors

Xiangya Hospital of Central South University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) Those who are eligible for skin infections caused by bacterial smears suggestive of G+ and G- in superficial wounds; (2) Patients aged 18-75 years; (3) Patients with good adherence and voluntarily using the protocol-setting groups for treatment

Exclusion criteria

Exclusion criteria: (1) Patients under 18 years of age and over 75 years of age; (2) Patients with porphyria and patients with light sensitivity; (3) Patients with hypersensitivity to mupirocin ointment or other polyethylene glycol-containing ointments; (4) Patients who are preparing for pregnancy, pregnant or breastfeeding; (5) Patients with psychiatric disorders.

Design outcomes

Primary

MeasureTime frame
The amount of bacterial DNA from wound by NGS sequencing;

Secondary

MeasureTime frame
Physician PGA score;Wound area;Degree of redness and swelling around the wound;Fluid seepage on the wound;Pain VAS assessment;Patients self-reported outcomes;

Countries

China

Contacts

Public ContactJuan Su

Xiangya Hospital of Central South University

540020068@qq.com+86 151 1640 8921

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026