A prospective observational study of cough challenge test and cough suppression test in chronic cough

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400085002

Enrollment

Unknown

Registered

2024-05-29

Start date

2024-06-01

Completion date

Unknown

Last updated

2024-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic cough

Interventions

Case series:NA

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age >18 years; 2. Cough is the main symptom and lasts for more than 8 weeks; 3. No obvious abnormality on chest radiographs or chest CT; 4. Voluntarily undergo cough provocation and suppression tests with capsaicin inhalation.

Exclusion criteria

Exclusion criteria: 1. pregnant or breastfeeding patients; 2. current smokers or smokers in the past two years; 3. history of acute upper respiratory tract infection within 8 weeks; 4. mental and cognitive dysfunction, hearing and communication disorders; 5. treatment for the etiology of chronic cough prior to the study with significant improvement; 6. other conditions that, in the opinion of the investigators, make the patient unsuitable for entry into the study.

Design outcomes

Primary

Measure	Time frame
Capsaicin Concentrations to elicit 2 Coughs and 5 Coughs;	—

Countries

China

Contacts

Public ContactXianghuai Xu

Tongji Hospital of Tongji University

05849@tongji.edu.cn+86 137 6445 9488

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026