rheumatoid arthritis
Conditions
Interventions
Test group:Sanwu Jiaowan+ Oral methotrexate
Control group:Oral methotrexate
Sponsors
The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Active RA that meets the diagnostic criteria of Western medicine. 2. Meets the diagnostic criteria of traditional Chinese medicine for cold dampness obstruction and the dialectical differentiation of cold dampness obstruction syndrome. 3. Age range from 18 to 65 years old, regardless of gender. 4. DAS28 score>2.6. 5. No biological agents have been used in the past month. 6. Willing to cooperate with observation and follow-up for more than 12 weeks, willing to voluntarily cooperate with questionnaire surveys, routine examinations, and the execution of treatment plans. 7. Sign the informed consent form for clinical research.
Exclusion criteria
Exclusion criteria: (1) Individuals with other rheumatic and immune diseases, such as systemic lupus erythematosus, Sjogren's syndrome, severe osteoarthritis, etc; (2) Individuals with concomitant cardiovascular diseases (coronary heart disease, pulmonary heart disease, cardiomyopathy, etc.) and arrhythmia; (3) Individuals with elevated ALT/AST levels exceeding three times the normal value (>120 U/L), or with elevated creatinine levels exceeding 177umol/L and urea nitrogen levels exceeding 7.0mmol/L; (4) Severe diseases such as lung (interstitial fibrosis), gastrointestinal tract, kidney, hematopoietic system or tumors, or various acute and chronic infections or other infectious diseases (hepatitis, tuberculosis, etc.); (5) Hormone dependence, long-term use of hormones; (6) Has contraindications and a history of allergies to experimental drugs; (7) Have a history of alcoholism, drug abuse, or neurological and psychiatric disorders (epilepsy, depression, etc.); (8) Pregnant or lactating women who have a recent birth plan; (9) Currently participating in clinical research on other drugs. (Note: Patients who meet any of the above criteria should be excluded and cannot be included in this trial.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ESR;CRP;DAS28 Disease Activity Score;Traditional Chinese Medicine Syndrome Points; | — |
Secondary
| Measure | Time frame |
|---|---|
| rheumatoid factor;Anti cyclic citrulline peptide antibody;VAS scores; | — |
Countries
China
Contacts
Public ContactLi Zhaofu
The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine; Yunnan University of Traditional Chinese Medicine
Outcome results
None listed