Liver cancer
Conditions
Interventions
Intervention group:Perioperative adjuvant (preoperative neoadjuvant + postoperative adjuvant) therapy
Sponsors
The Eighth Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Clinical diagnosis of hepatocellular carcinoma or pathologically confirmed hepatocellular carcinoma by puncture biopsy (Clinical diagnosis of hepatocellular carcinoma is made according to the Guidelines for Primary Liver Cancer Diagnosis and Treatment 2022) 2. Have not received systematic therapy related to hepatocellular carcinoma before; 3. At least one measurable lesion meets RECIST v1.1 criteria 4. HCC with CNLC stage IIb or IIIa; 5. Potential resectable liver cancer in liver cancer stages Ia, Ib, IIa and IIb and IIIa in China; 6. Eastern Cooperative Oncology Group performance status (ECOG PS) score 0-1
Exclusion criteria
Exclusion criteria: 1. The patient has been diagnosed with intrahepatic cholangiocarcinoma, mixed liver cancer, or other liver malignancies 2. Have had malignant tumors other than HCC within the past 5 years; 3. The postoperative pathological diagnosis was non-R0 resection or did not meet the criteria for radical postoperative diagnosis of liver cancer (the criteria for radical postoperative diagnosis of liver cancer are determined according to the Diagnosis and Treatment Guidelines for Primary Liver Cancer 2022). 4. Is or has received an organ transplant or allogeneic bone marrow transplant; 5. Liver function Child-pugh B or C grade
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Major pathological response ;Overall survival;Objective Response Rate;Pathological complete response;Immune-related adverse events; | — |
Countries
China
Contacts
Public ContactZheng Zhou
The Eighth Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed