Effect of acupuncture at Siguan Point on cerebral neurometabolites and functional changes in patients with amnestic mild cognitive impairment

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400084967

Enrollment

Unknown

Registered

2024-05-29

Start date

2024-06-01

Completion date

Unknown

Last updated

2024-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

amnestic mild cognitive impairment

Interventions

1:Patients in AMCI Group were treated with acupuncture at Hegu and taichong points (Fig. 2) . The location of"Siguan acupoint" refers to the national standard of the People's Republic of China"Acupoin

2:The Observation Group, without treatment, only received MRI examination

Eligibility

Sex/Gender

All

Age

55 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) subjective memory complaints, (2) objective memory loss, defined as a delayed recall score lower than the education-adjusted score on the Wechsler Memory Scale logical memory test (WMS) , (3) clinical dementia score (CDR) of 0.5; (4) the score of mini-mental state examination (MMSE) is equal to or higher than 24 points (total score is 30 points) , (5) the general cognitive and functional performance is fully preserved, and the diagnosis of AD can not be made after assessment by neurologists; (6) no diagnosis of depression (geriatric depression scale, GDS score & LT; 5) .

Exclusion criteria

Exclusion criteria: (1) A History of neurological disorder trauma, previous or ongoing use of non-AD-related drugs known to affect brain function, and a history of alcohol or drug abuse within two years (5) left-handedness and (6) contraindications such as large metallic foreign bodies in the body and artificial pacemaker implantation.

Design outcomes

Primary

Measure	Time frame
function magnetic resonance imaging;magnetic resonance spectroscopy;	—

Secondary

Measure	Time frame
(clinical dementia rating, CDR);( Montreal cognitive assessment , MoCA);(mini-mental state examination,MMSE);	—

Countries

China

Contacts

Public ContactLin Jiangnan

From the Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), T

linjiangnan@zcmu.edu.cn+86 183 5700 1228

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026