Neuropathic pain
Conditions
Interventions
Dexmedetomidine group:Intravenous dexmedetomidine (0.5 µg/kg) loading dose over 15 mins on induction of anaesthesia, followed by continuous infusion of dexmedetomidine at 0
saline group:0.9%saline
Sponsors
The University of Hongkong - Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists (ASA) Physical Status I to III; 2. Patients (aged 18-75) undergoing elective VATS under general anaesthesia;
Exclusion criteria
Exclusion criteria: 1. Severe heart failure or left ventricular ejection fraction 100 IU/L or Child-Pugh Class B; 4. Impaired renal function with preoperative serum creatinine level > 120 µmol/L or eGFR 35 kg/m^2; 8. Chronic opioid use (defined as opioid consumption for 3 months or more) ; 9. Alcohol or drug abuse; 10. Pregnancy or breastfeeding; 11. Inability to comprehend Chinese language;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of chronic postoperative pain 3 months after VATS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of moderate to severe chronic postoperative pain 3 and 6 months after VATS;Acute postoperative pain (NRS) and opioid consumption over the first 3 postoperative days;Degree of pain interference with daily activities and sleep;7.Health-related quality of life; | — |
Countries
China
Contacts
Public ContactMu Jingjing
The University of Hongkong - Shenzhen Hospital
Outcome results
None listed