Pruritus
Conditions
Interventions
Butorphanol group:Butorphanol tartrate injection, 2 mg/ml. total 0.5 ml, 1 mg, with saline to 6 ml, epidural push in the PACU.
control group:Saline (0.9% Nacl), 6 ml given epidurally in the PACU.
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Participation is voluntary and the patient understands and signs or has an informed consent form signed on his/her behalf by his/her immediate family members; Age: 18-80 years old; Patients who undergo surgical procedures and volunteer for epidural intraoperative as well as postoperative analgesia; Indications for epidural analgesia: normal coagulation; platelets =75×10^9 /L;
Exclusion criteria
Exclusion criteria: Abnormal coagulation function or platelet <75×10^9 /L; systemic infection or the presence of infection foci at the puncture site; failure to correctly stop anticoagulant and antiplatelet drugs; circulatory instability; psychiatric disorders that can not be cooperated with the patient; limb autonomy movement disorders; Those who are uncertain of the success of epidural operation due to trauma, deformity, implant, low back pain, etc. at the puncture site; Those who have serious abnormalities of vital organ function before the operation; Patients who cannot understand and use epidural analgesic pumps safely; Those who lack the ability to express and understand, cannot communicate effectively, and do not understand the level of itching and analgesic scores; Patients with a clear preoperative history of allergy to Butorphanol injection; Patients with pre-existing pruritus: e.g., history of dermatologic diseases, gout, rheumatoid diseases; Patients with perioperative onset of allergy to antibiotics, anesthetics, or latex; Patients who have received allogeneic blood transfusions in the last 1 month; Patients with serious complications in the perioperative period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of pruritus 24h after the surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Site of itching, time of occurrence, degree and duration; use of relevant remedial medication or not;Patient's postoperative sleep quality;Adverse effects associated with epidural opioid analgesia;Effectiveness of epidural analgesia;Patient satisfaction after discharge; | — |
Countries
China
Contacts
Public ContactJing Cang
Department of Anesthesiology, Zhongshan Hospital, Fudan University
Outcome results
None listed