amnestic mild cognitive impairment
Conditions
Interventions
Acupuncture group:Acupuncture at Shenting, Baihui, Sanyinjiao, Taixi, Dazhong
Sham acupuncture group:Sham acupuncture at 8 non-acupoints
Sponsors
Chengdu University of Traditional Chinese Medicine; Affiliated hospital of Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients who meet 8 following criteria will be included: (1) diagnosis of aMCI according to the Jak/Bondi 2014 diagnostic criteria; (2) fifty to eighty years of age, without limitation of sex; (3) course of disease=3 months; (4) the Clinical Dementia Rating (CDR) score is 0.5; (5) the Hachinski Incheinic Score (HIS)=4; (6) education years=8 (including vocational education) and correct understanding the completion of scales; (7) volunteering to cooperate and sign an informed consent form; (8) no contraindications to magnetic resonance imaging (MRI) scanning.
Exclusion criteria
Exclusion criteria: Patients will be excluded if they meet any of the following criteria: (1) receiving treatment that interferes with cognitive function (e.g., the treatment of acute psychotic illness, such as memantine, rivastigmine, donepezil, oxiracetam, and sodium oligomannate capsules); (2) a history of neurological conditions affecting cognitive function confirmed by examination, except in patients with suspected early AD (including Parkinson's disease, vascular dementia, brain tumour, traumatic brain injury, or other diseases which might lead to neurological injury and abnormal brain structure). Presence of a systemic diseases that could cause cognitive decline (such as anaemia, Hashimoto's encephalopathy, metabolic encephalopathy, hepatic encephalopathy, and renal encephalopathy); (3) the brain MRI showing infection or other local lesions, infarction in vital memory brain areas, multiple embolic infarctions, or severe white matter lesions (Fazekas score=3); (4) a history of tumour, psychiatric illness (e.g., bipolar disorder, schizophrenia), or severe anxiety (Hamilton anxiety [HAMA] scale score=29), major epression (Hamilton Depression [HAMD] scale score=24); (5) severe haemorrhagic disease, bleeding tendency, or skin infection; (6) severe drug dependence, smoking, drug, or alcohol abus ; (7) pregnant, lactating females, or potentially pregnant; (8) receipt of any acupuncture treatment or participation in other clinical trials within 6 months before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer's Disease Assessment Scale - Cognitive; | — |
Secondary
| Measure | Time frame |
|---|---|
| Word recall and word recognition score of Alzheimer's Disease Assessment Scale - Cognitive;Hamilton Anxiety Scale;Hamilton Depression Scale;Pittsburgh Sleep Quality Index; | — |
Countries
China
Contacts
Public ContactFanrong Liang
Chengdu University of Traditional Chinese Medicine; Affiliated hospital of Chengdu University of Traditional Chinese Medicine
Outcome results
None listed