idiopathic pulmonary fibrosis
Conditions
Interventions
control group:nidanib
experimental group:azithromycin combined with nidanib
Sponsors
Tongren Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) patients with IPF; (2) = 75 years old, Male/Female.
Exclusion criteria
Exclusion criteria: (1) can't tolerate Nitanib and Azithromycin; (2) with obvious pulmonary infections requiring anti infection treatment; (3) taking prednisone exceeding 10mg/d within 1 month before selection; (4) received immunosuppressive therapy within 1 month before selection; (5) with malignant tumors within 5 years before selection; (6) long term use (>1 week) of drugs such as amiodarone that may cause pulmonary fibrosis before selection; (7) received interferon, N-acetylcysteine, pirfenidone, or other anti fibrotic drugs within 1 month before selection; (8) participated in other drug trials within 3 months before selection; (9) other serious systemic diseases and organ dysfunction; (10) pregnant women, lactating women, or those who have recently planned to have children and are unable to take effective contraceptive measures; (11) with obvious liver and kidney dysfunction (ALT>1.5 times the upper limit of normal value; Cr higher than the upper limit of normal value); (12) researchers believe that there are any individuals who are not suitable for selection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| forced vital capacity; | — |
Secondary
| Measure | Time frame |
|---|---|
| vital capacity;diffusion capacity for carbon monoxide of lung;forced expiratory volume in the first second;6-minute walk test;chest high resolution CT;St George' s respiratory questionnaire;Borg dyspnea score;c-reactive protein;erythrocyte sedimentation rate;immunoglobulin;echocardiography;arterial blood gas analysis ;laminin;type IV collagen;type III procollagen N-terminal peptide;hyaluronic acid; | — |
Countries
China
Contacts
Public ContactYiliang Su
Tongren Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed