Stroke
Conditions
Interventions
Control group:The same probiotic compound administered via a nasogastric tube using conventional delivery techniques at 4 times daily doses of 20-40mg per dose, with a maximum of up to 80mg per dose i
Colonic Targeted Delivery Group:Probiotic compound preparation delivered through a nasogastric tube using colon-targeted delivery technology (probiotic compound formulation that remains structurally s
Sponsors
Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital.
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.According to the guidelines for the management of spontaneous intracerebral hemorrhage, the management guidelines for acute ischemic stroke, and the CT imaging diagnosis for stroke, 2. GCS score = 8 3. Age between 18 and 80, any gender 4. Individuals without legal capacity will have their participation determined by a legal representative, who will sign the informed consent form voluntarily.
Exclusion criteria
Exclusion criteria: 1. After cardiopulmonary resuscitation or brain death (brain death criteria based on Determination of Brain Death/Death by Neurologic Criteria). 2. Previous or pre-existing history of gastrointestinal surgery, or experiencing gastrointestinal complications (intestinal obstruction, gastrointestinal bleeding). 3. Hemodynamic instability (norepinephrine >0.5ug/kg/min, according to Surviving sepsis campaign: international guidelines for management of sepsis). 4.Broad-spectrum antibiotics (cephalosporins of the fourth generation or above, or combination therapy) are required upon admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The percentage of Bristol Stool Chart types 3-5; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bowel movements frequency;Incidence of gastrointestinal complications;Gut microbiota diversity;Intestinal Flora Metabolites;ICU hospitalization time;14 days survival rate;60 days survival rate; | — |
Countries
China
Contacts
Public ContactMingli Zhu
Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital.
Outcome results
None listed