CHB
Conditions
Interventions
CHB:None
CHB and MAFLD:None
Sponsors
Beijing You 'an Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
16 Years to 60 Years
Inclusion criteria
Inclusion criteria: ? CHB meets the 2022 Chronic Hepatitis B Prevention and Treatment Guidelines, HBsAg positive >6 months, NA treatment, HBsAg < 1500IU/ml, HBeAg negative, HBV DNA < 10 IU/mL. ? MAFLD meets the following diagnostic criteria: liver steatosis is diagnosed by abdominal B-ultrasound or Fibroscan or hepatic adipose measurement MRI (adipose lesion is classified as mild to moderate or severe according to the threshold value of the above detection means). One of the following three conditions: 1) overweight or obese (BMI=23kg/m2); 2) Diabetes mellitus; 3) Lean/normal weight patients meet at least 2 metabolic abnormalities
Exclusion criteria
Exclusion criteria: ? Patients with HCV infection and autoimmune liver disease; ? History of heavy alcohol consumption (alcohol intake > 210g/ day for men and > 140g/ day for women); ? Secondary hepatic steatosis caused by drugs, such as tamoxifen, hormones, etc.; (4) Pregnant and lactating women and patients who are preparing to give birth in the near future; ? Patients with cirrhosis or liver cancer in the past or now; ? Other serious diseases that may affect the nutritional status of the body, such as malignant tumors, serious organic or mental diseases such as heart, lung, kidney, etc.; ? Neutrophil count 34umol/L.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 48 week HBsAg clearance rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quantitative decrease in HBsAg at 48 weeks;HBV DNA undetectable rate;HBsAg serological conversion rate;PEG-IFN adverse reactions; | — |
Countries
China
Contacts
Public ContactCao Zhenhuan
Beijing You 'an Hospital, Capital Medical University
Outcome results
None listed