Prognosis for patients undergoing elective surgery in neurosurgery
Conditions
Interventions
Sponsors
Huzhou Central Hospital, The Affiliated Central Hospital of Huzhou University (The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective neurosurgery under general anesthesia; 2. ASA grade I ~ III; 3. Age 18-80 years old, clear mind; 4. Agree to participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who are participating or planning to participate in any interventional clinical trial; 2. Patients with severe hepatic and renal insufficiency; 3. Contraindications to the use of a2-adrenergic agonists; 4. Dexmedetomidine allergy; 5. Severe bradycardia (heart rate <40 beats/min), sick sinus syndrome or second to third degree atrioventricular block; 6. Severe mental illness and communication difficulties; 7. Use amiodarone or dexmedetomidine within 30 days; 8. Ejection fraction < 30% or severe heart failure, myocardial infarction within 7 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative recovery time and quality of recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of intraoperative hypotension, the type of vasopressor used and the amount of drugs;Adverse reactions during awakening;The incidence and severity of pain on the day after surgery and within 3-5 consecutive days after surgery, the type and amount of intervention drugs, and the effect after intervention;duration of stay in the postanesthesia care unit;Incidence and severity of delirium on the day after surgery and within 3 to 5 consecutive days after surgery;Recovery on the day after surgery and within 3-5 consecutive days after surgery;Anxiety score on the day after surgery and for 3-5 consecutive days after surgery;Depression score on the postoperative day and for 3-5 consecutive days postoperatively;Sleep quality on the day after surgery and for 3-5 consecutive days after surgery;The incidence, severity and grade of epilepsy, as well as the type and dosage of intervention drugs during postoperative to discharge and within 1 month of postoperative follow-up; | — |
Countries
China
Contacts
Public ContactHe Liu
Huzhou Central Hospital, The Affiliated Central Hospital of Huzhou University (The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University)
Outcome results
None listed