carotid endarterectomy
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) Age between 40 and 75 years; (2) Unilateral carotid artery stenosis with symptoms =50% or asymptomatic unilateral carotid artery stenosis =70%; (3) American Society of Anesthesiologists (ASA) classification II to III; (4) Undergoing carotid endarterectomy (CEA) treatment.
Exclusion criteria
Exclusion criteria: (1) Patients who take antidepressant and sedative drugs for a long time; (2) Individuals with a history of neurosurgical surgery; (3) Patients with respiratory insufficiency and severe heart valve disease; (4) Individuals with contraindications to the medication used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Internal jugular venous bulb oxygen saturation;arterial partial pressure of oxygen;Arterial oxygen saturation;Arterial blood lactate;Arterial hemoglobin;MMSE score;Partial pressure of oxygen in the jugular vein bulb;jugular vein bulb blood lactate;Hemoglobin from internal jugular vein; | — |
Secondary
| Measure | Time frame |
|---|---|
| S100 calcium binding protein beta subunit;mean arterial pressure;heart rate;nausea and vomiting;hoarseness and hematoma,;phrenic nerve block;Intraoperative dosage of vasoactive drugs;Blocking time, anesthesia time, surgical time; | — |
Countries
China
Contacts
Suzhou Hospital Affiliated to Nanjing Medical University