Breast cancer
Conditions
Interventions
Index test:Lymph node virtual staining-diagnostic model
Sponsors
Yunnan Cancer Hospital (The Third Affiliated Hospital of Kunming Medical University )
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: part 1: 1) 18-75 years old female patients with breast cancer; 2) Undergo surgical excision of breast cancer + sentinel lymph node biopsy/axillary lymph node dissection 3) Lymph nodes with clear postoperative paraffin pathological results; part 2: 1) 18-75 years old 2) Surgical resection of thyroid, lung, gastrointestinal and gynecologic tumors accompanied by lymph node pathology 3) Lymph nodes with clear postoperative paraffin pathological results; part 3: ) 18-75 years old female patients with breast cancer; 2) Undergo surgical excision of breast cancer+sentinel lymph node biopsy; 3) Sentinel lymph nodes with clear postoperative paraffin pathological results;
Exclusion criteria
Exclusion criteria: part 1/ part 2: 1. Lymph node diagnosis is missing 2. Absence of lymph node component in the slice part 3: 1) Sentinel lymph node diagnosis is missing; 2) Absence of lymph node component in the frozen slice.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whole slide image of lymph node (H&E/IHC);Lymph node metastasis status;Accuracy, Sensitivity, Specificity;Area under the curve;Peak Signal-to-Noise Ratio;Multi-Scale Structural Similarity;Pearson correlation coefficient; | — |
Secondary
| Measure | Time frame |
|---|---|
| Positive predictive value;Negative predictive value; | — |
Countries
China
Contacts
Public ContactGuojun Zhang; Zhicheng Du
Yunnan Cancer Hospital (The Third Affiliated Hospital of Kunming Medical University ); School of Medicine, Xiamen University
Outcome results
None listed