Ischemic stroke
Conditions
Interventions
Case series:none
Sponsors
Affiliated Jinling Hospital, Medical School of Nanjing University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) Age=18 years old; 2) Acute anterior circulation ischemic stroke, confirmed by imaging (CTA/MRA/DSA) with occlusion of large vessels in the anterior circulation (ICA, MCA-M1, ACA-A1); 3) Received mechanical thrombectomy; 4) Successful recanalization of the responsible vessel (postoperative mTICI = 2b); 5) Patients or family members signing a written informed consent for the clinical study.
Exclusion criteria
Exclusion criteria: 1) Pre-stroke mRS =2 points; 2) Interventional time window >24 hours; 3) Preoperative imaging confirmed intracranial hemorrhage; 4) Patients are likely to be unable to cooperate with the MRI examination 5) Contraindications to MRI: e.g. claustrophobia, metallic implants in the body such as pacemakers; 6) Poor quality of MRI images difficult to analyses; 7) Severe organic disease with life expectancy <90 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 90-day mRS score of 0-2; | — |
Secondary
| Measure | Time frame |
|---|---|
| 90-day mRS score of 0-1;90-day mRS score;Early neurological improvement (=4 reduction in NIHSS score at 24 hours postoperatively);Early neurological deterioration (increase in NIHSS score =4 at 24 hours postoperatively);Delayed neurological improvement (=4 reduction in NIHSS score at 7 days postoperatively);90-day NIHSS score;change in NIHSS score at 90 days;malignant cerebral edema;intracranial haemorrhage;Symptomatic intracranial haemorrhage;Change in infarct volume;New infarction;Low perfusion volume change; | — |
Countries
China
Contacts
Public ContactWusheng Zhu
Affiliated Jinling Hospital, Medical School of Nanjing University
Outcome results
None listed