AML
Conditions
Interventions
AZA plus Ven:None
AZA plus low dose Ven:None
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age = 65 years old; (2) Complies with AML (non APL) according to WHO diagnostic criteria; (3) Previously untreated; (4) No uncontrolled current infections (new infections, broad-spectrum antibiotics with body temperature still above 38 ? after 72 hours, excluding other non infectious factors); (5) IACA assessed as unsuitable or fragile.
Exclusion criteria
Exclusion criteria: (1) Patients with central nervous system involvement; (2) Patients with life-threatening or treatment-influencing complications who merge; (3) Patients with severe allergies to azacytidine or vinpoclavone; (4) Patients with clinical symptoms of brain dysfunction or severe mental illness who cannot understand or follow the protocol; (5) Patients with other malignant tumors that require treatment; (6) According to the judgment of the researchers, the patient has other unsuitable enrollment situations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite complete remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall response rate;Complete remission rate;Relapse Rate;Overall survival;Relapse free survival;Event free survival;Minimal residual disease;Adverse event;Transfusion dependence; | — |
Countries
China
Contacts
Public ContactRu Feng
Beijing Hospital
Outcome results
None listed