chronic atrophic gastritis
Conditions
Interventions
51-60 years old group:None
61-70 years old group:None
71-80 years old group:None
21-30 years old group:None
31-40 years old group:None
41-50 years old group:None
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Having normal gastric mucosa:regular pits with round openings in gastric corpus under confocal laser endomicroscopy; 2.Knowingly and voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: 1.Vonlunteers with abdominal pain, reflux and dyspepsia were scored 4 points in GSRS; 2.Gastroscopy revealed gastric cancer, peptic ulcer, erosive gastritis (grade 2 and above), moderate and severe atrophic gastritis, dysplasia or other organic diseases of the gastrointestinal tract; 3.Previous or current urea breath test and serum H. pylori antibody positive individuals 4.Pepsinogen I = 70ug/L, or a ratio of pepsinogen I/II = 3 5. History of severe cardiopulmonary insufficiency, liver and kidney insufficiency, endocrine disorder, hematopoietic dysfunction; 6. History of abdominal surgery (except appendectomy and cesarean section); 7. Severe anxiety or depression (GAD-7 or PHQ-9 >= 15 points); 8.Patients with bad habits of smoking and drinking; 9. Pregnant or lactating women in the medical history; 10. Allergic to sodium fluorescein; 11. Patients deemed unsuitable for participation in this clinical trial by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pCLE images; | — |
Secondary
| Measure | Time frame |
|---|---|
| biomarker of gastric mucosa aging; | — |
Countries
China
Contacts
Public ContactLing Liu
West China Hospital, Sichuan University
Outcome results
None listed