pain
Conditions
Interventions
Afentanil combined with propofol group (AP group):During the induction period, 7 µg/kg of Afentanil was slowly injected intravenously and pushed for more than 10 s. After 30 s, propofol 2 mg/kg was in
Afentanil combined with Remazolam benzoate group (AR group):During the induction period, 7 µg/kg of Afentanil was injected intravenously and pushed for more than 10 s. After 30 s, 0.2 mg/kg of remazol
Sufentanil combined with Remazolam benzoate Group (SR group):During the induction period, Sufentanil was slowly injected intravenously with 0.1 µg/kg, and then pushed for more than 10 s. After 1-3 min
Sufentanil combined with propofol group (SP group):During the induction period, Sufentanil was slowly injected intravenously with 0.1 µg/kg and pushed for more than 10 s. Propofol was injected intrave
Sponsors
Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Patients undergoing elective painless gastroscopy and colonoscopy; 2) Age 18-65 years old, gender is not limited; 3) Body Mass Index (BMI) : 18.5~28 kg/m2; 4) American Society of Anesthesiologists (ASA) Grade I to II; 5) Operation time within 45 min; 6) The subjects voluntarily participate in the experiment and sign the informed consent of the experiment.
Exclusion criteria
Exclusion criteria: 1) The subject explicitly refuses to participate in the study; 2) Patients with a history of allergy to opioids, benzodiazepines, propofol, flumazenil or naloxone; 3) Use beta blockers, anti-anxiety drugs, antidepressants; 4) Suspected abuse of narcotic analgesics or sedatives, and alcohol abuse; 5) Electrocardiogram: heart rate 100 times /min or severe arrhythmia; 6) A history of acute respiratory infection within 2 weeks with no cure; 7) Have a history of serious heart, brain, lung, liver, kidney or metabolic diseases, neuromuscular system diseases (such as myasthenia gravis), mental illness; 8) Preoperative systolic blood pressure of hypertensive patients > 180 mmHg and/or diastolic blood pressure > 110 mmHg, or patients with low blood pressure < 90/60 mmHg; 9) Patients with a history of gastrointestinal tract change; 10) Patients with a history of recovery from abnormal surgical anesthesia; 11) Predict those who may develop or have developed difficult airway, such as modified Markov scale ?-?; 12) Pregnant or lactating women and patients (including men) who plan to have a baby within 3 months 13) Other subjects whom the investigator considers inappropriate to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ramsay rating; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Blood pressure;Oxygen saturation;respiratory rate;MOAA/S score;Subject satisfaction;VAS score; | — |
Countries
China
Contacts
Public ContactRen Yingbo
Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University
Outcome results
None listed