Pharmacodynamic response of sedatives in subjects with different body weight and OSA levels
Conditions
Interventions
Model establishment:The initial dose of remimazolam Tosylate will be infused at a rate of 0.2mg/kg/h, with an upregulation of 0.2mg/kg/h every 15 minutes. The infusion will be stopped when the suject
External Validation:The initial dose of remimazolam Tosylate will be infused at a rate of 0.2mg/kg/h, with an upregulation of 0.2mg/kg/h every 15 minutes. The infusion will be stopped when the subject
Sponsors
Eye & ENT Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 45 volunteers with different weight ranges, who received sleep monitoring in the sleep ward of Fudan University Affiliated Eye & ENT Hospital from May 2024 to Dec 2024 were included. Inclusion criteria: 1. 18-45 years old, 2. American Society of Anesthesiologists (ASA) Grades I-II, 3. Admission laboratory examination evaluates normal liver and kidney function, 4. 12 with normal weight (18.5 kg/m^2 = BMI = 35 kg/m^2), 5. Obtaining a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Allergy to any component of benzodiazepines and remimazolam tosylate; 2. Who have been using anesthetic analgesics, nonsteroidal anti-inflammatory drugs, and benzodiazepine hypnotics for a long time 3. With positive radial artery Allen test 4. Have participated in clinical trials of drugs or medical devices as a subject within the past 3 months 5. Donate more than 400 milliliters of blood within one month before the experiment 6. Pregnancy, lactation, potential pregnancy, and planned pregnancy; 7. History of abnormal recovery from previous surgical anesthesia: intraoperative awareness and postoperative delirium; 8. History of difficult tracheal intubation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the relationship between MOAA/S and the plasma concentrations of remimazolam tosylate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Observer’s Assessment of Alertness and Sedation scale, MOAA/S;Hemodynamic monitoring;Polysomnography (PSG); | — |
Countries
China
Contacts
Public ContactYuan Han
Eye & ENT Hospital of Fudan University
Outcome results
None listed