Comparison of prognosis and safety of endovascular thrombectomy and bridging therapy in acute anterior circulation large vessel occlusion stroke

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400084811

Enrollment

Unknown

Registered

2024-05-24

Start date

2024-06-01

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral apoplexy

Interventions

Bridge group:None

Eligibility

Sex/Gender

All

Age

No minimum to 100 Years

Inclusion criteria

Inclusion criteria: (1) Age =18 years old; (2) The diagnosis of acute ischemic stroke met the diagnostic criteria of the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018; (3) In patients with acute anterior circulation great vascular occlusive stroke, the diseased vessels included internal carotid artery, anterior cerebral artery A1 segment, middle cerebral artery M1 segment, and proximal M2 segment;(4) In patients with intravenous thrombolysis, the time from onset to intravenous administration was < 4.5h; (5) Ischemic penumbra was confirmed by multi-mode magnetic resonance imaging (MRI) in patients with endovascular therapy, whose onset time to femoral artery puncture was <6h, or stroke after awakening with unknown onset time; (6) Preoperative modifiedRankinScale (mRS) score <2; (7) Family members sign informed consent

Exclusion criteria

Exclusion criteria: (1) Imaging diagnosis was hemorrhagic stroke; (2) There are contraindications of intravenous thrombolysis; (3) Combined with post-circulation acute cerebral infarction; (4) Life expectancy is less than 6 months; (5) The follow-up data were incomplete. (6) Preoperative blood glucose 22.2mmol/L.

Design outcomes

Primary

Measure	Time frame
The rate of vascular revascularization and nerve function 90 days after operation were observed;The proportion of good neurological outcomes at 90 days after surgery;	—

Secondary

Measure	Time frame
90-day mortality rate;Incidence of symptomatic intracranial hemorrhage within 48 hours;Proportion of patients with any intracranial hemorrhage within 48 hours;Surgery-related complications;The incidence of serious adverse events;	—

Countries

China

Contacts

Public ContactFuwan Yao

Liujiang District People's Hospital, Liuzhou, Guangxi, China

94657530@qq.com+86 136 3303 4009

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026