Parkinson's disease
Conditions
Interventions
Experimental-control group:Participants received TI stimulation at the first time, and received sham stimulation at the second time, with a 7-day interval between the two stimulation.
Control-experimental group:Participants received sham stimulation at the first time, and received TI stimulation at the second time, with a 7-day interval between the two stimulation.
Sponsors
School of Exercise and Health, Shanghai University of Sport
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Adult male or female, aged 40 years or older; (2) Diagnosis of idiopathic Parkinson's disease according to the Brain Bank criteria, with onset after 40 years of age; (3) Response to levodopa-based drugs; (4) Hoehn and Yahr (H&Y) Stage 1.5-2.5; (5) Ability to walk alone for at least five minutes without the use of assistive devices; (6) No occurrence of severe Freezing Of Gait (FOG).
Exclusion criteria
Exclusion criteria: (1) Presence of other central neurological disease affecting the experiment; (2) Mild or greater cognitive impairment, as indicated by a MoCA score of =23; (3) Orthopedic or other health conditions that may affect gait or balance; (4) MRI contraindications such as claustrophobia; (5) A history of antipsychotic medication, antidepressant medication, or other medications that may affect dopamine levels; (6) History of antipsychotic, antidepressants, or other medication usage that may affect dopamine levels, or a history of other severe psychiatric illnesses; (7) Metal implants in the head or heart; (8) A history of electroshock; (9) Ongoing participation in other gait and balance-related interventions; (10) Physician-diagnosed risk factors for cardiovascular exercise.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Movement Disorder Society Unified Parkinson’s Disease Rating Scale Part III;brain activation and network functional connectivity;Blinding and adverse events questionnaire; | — |
Secondary
| Measure | Time frame |
|---|---|
| Movement Disorder Society Unified Parkinson’s Disease Rating Scale Part II;Montreal Cognitive Assessment;Time up and go tests;amplitude of low-frequency fluctuations;regional homogeneity;Balance biomechanical index;Gait biomechanical index;Dual-task cost; | — |
Countries
China
Contacts
Public ContactYu Liu
Shanghai University of Sport
Outcome results
None listed