Type 2 Diabetes
Conditions
Interventions
Treatment group:After 7-10 days of intensive insulin pump treatment, the combination of insulin glargine, metformin hydrochloride and liraglutide was given
Control group:After 7-10 days of intensive insulin pump therapy, metformin hydrochloride, daglipzin and acarbose were given combined therapy
Sponsors
Guangrao County People's Hospital of Dongying city
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Screening patients diagnosed with type 2 diabetes mellitus (clinical diagnosis) and disease duration =5 years; (2) Poor blood glucose control (HbA1c=7.5% and =10.5%), FPG>7.5mmol/L or 2hFBG>10mmol/L; (3) Maintaining the current stable regimen for at least =3 months (treatment with 2-3 oral hypoglycemic drugs, such as metformin, sulfonylurea, STZ, glienides, a-glucosidase inhibitors, DPP-4i, SGLT-2i, etc.); (4) Age =18 years, BMI=20kg/m2.
Exclusion criteria
Exclusion criteria: (1) GLP-1RA and various types of insulin have been used in the last 3 months; (2) Have participated in other scientific research or clinical trial projects within the past 4 weeks; (3) DKA or NKHS has ever occurred; (4) Have a history of major cardiovascular disease: acute or chronic myocardial infarction, unstable angina pectoris or malignant arrhythmia, acute or chronic heart failure (NYHA grade ?, ?), and have a history of major cardiac or interventional vascular surgery; (5) Rapid progression of kidney disease or other types of kidney disease that have not yet been diagnosed; (6) Active liver disease or liver insufficiency (AST or ALT greater than 2 times the upper limit of normal); (7) Proliferative retinopathy (fundus hemorrhage); (8) is currently pregnant or breastfeeding; (9) A long history of uncontrolled alcoholism or drug abuse; (10) History of unstable mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting Blood Glucose;Glycated Hemoglobin ;Fasting C-peptide; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glycated albumin;Full fasting insulin;Triglycerides;Total cholesterol;Low-density lipoprotein cholestero;serum creatinine;cystatin C;24-hour urinary protein quantity;hypersensitive reactive protein; | — |
Countries
China
Contacts
Public ContactGao Yuan
Department of Endocrinology, Guangrao County People's Hospital of Dongying city
Outcome results
None listed