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A single-center, prospective, observational clinical study evaluating the association of peripheral blood soluble CD30 with Brentuximab Vedotin in combination with CHP in adults with newly diagnosed peripheral T-cell lymphoma

A single-center, prospective, observational clinical study evaluating the association of peripheral blood soluble CD30 with Brentuximab Vedotin in combination with CHP in adults with newly diagnosed peripheral T-cell lymphoma

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400084778
Enrollment
Unknown
Registered
2024-05-24
Start date
2024-06-01
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

peripheral T-cell lymphoma

Interventions

case series:None

Sponsors

The First Affiliated Hospital of Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. According to the European and American lymphoma classification criteria revised by WHO in 2016, the patient was newly diagnosed with CD30+ PTCL. The eligible histological types included ALK-positive sALCL, ALK-negative sALCL, PTCL-NOS, AITL, EATL and HSTCL. 2. Age =18 3. Have not received anti-lymphoma therapy; 4. Patients treated with Brentuximab Vedotin combined with CHP were selected by clinicians 5. PET-CT or CT/MRI shows at least one two-dimensional measurable lesion (maximum diameter > 1.5cm) 6. women of childbearing age must be confirmed by pregnancy test not pregnant, and willing to take effective measures during the test period and =12 months after the last dose of contraception; Pregnant and lactating women cannot participate; All male subjects used contraception during the study period and =3 months after the last dose 7. can provide informed consent, can understand and comply with the study requirements.

Exclusion criteria

Exclusion criteria: With severe mental illness;

Design outcomes

Primary

MeasureTime frame
Objective response rate;

Secondary

MeasureTime frame
complete response rate;Progression-free survival;overall survival;

Countries

China

Contacts

Public ContactHongyan Tong

The First Affiliated Hospital of Zhejiang University School of Medicine

ruicostas610@sina.com+86 139 5812 2357

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026