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Comparison of the effects of pupil dilation and ciliary muscle paralysis of 1% tropicamide, 0.5% tropicamide and 1% cyclopentolate

Comparison of the effects of pupil dilation and ciliary muscle paralysis of 1% tropicamide, 0.5% tropicamide and 1% cyclopentolate

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400084750
Enrollment
Unknown
Registered
2024-05-23
Start date
2024-05-31
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes mellitus, refractive error

Interventions

intervention group:1% tropicamide and 2.5% phenylephrine medication
control group: 0.5% tropicamide and 0.5% phenylephrine medication
control group:1% cyclopentolate

Sponsors

Tianjin Medical University Eye Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
8 Years to 70 Years

Inclusion criteria

Inclusion criteria: Right eye refraction was used as the screening criterion, -0.50D>refraction>-6.00D, astigmatism<2.00D, refractive error<1.00D, 10mmHg<IOP<21 mmHg.

Exclusion criteria

Exclusion criteria: (1) Any previous internal eye surgery, such as cataract extraction or vitrectomy (2) The presence of other eye diseases that may affect the iris or pupil, such as eye trauma, iris redness, glaucoma, pseudoexfoliation syndrome, uveitis, etc. (3) Use of medication that affects the pupil, such as Hirschsprung's Bromide. (4) Pupil adhesion (5) People who are allergic to drugs affecting the function of autonomic nerves and pupil-dilating drugs taken before the examination. (6) Any condition that prevents accurate pupil size measurement, such as obvious corneal clouding, anterior chamber blood, amblyopia in both eyes, strabismus, refractive error, or poor co-operation of the patient. (7) Patients with systemic autonomic dysfunction such as tardive dyskinesia, upright hypotension, gastrointestinal tract dysfunction, etc. (8) Patients with a history of wearing contact lenses within one month.

Design outcomes

Primary

MeasureTime frame
Pupil diameter;Amplitude of accommodation;Residual regulation;

Secondary

MeasureTime frame
Axial length;Central corneal thickness;Lens thickness;White to White;Aqueous depth;Flat meridian/K1;Steep meridian/K2;Patient discomfort level;

Countries

China

Contacts

Public ContactWei Ruihua

Tianjin Medical University Eye Hospital

weirhua2009@126.com+86 139 2068 5016

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026