Spinal Surgery
Conditions
Interventions
Sponsors
The Second Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. For patients undergoing elective lumbar decompression and fusion surgery; 2. Age 18-65 years, gender unlimited; 3. ASA grade I-lll; 4. After fully explaining the content of the clinical trial participants should voluntarily join and sign the informed consent;
Exclusion criteria
Exclusion criteria: 1. Patients with a known allergy to opioids or opioid intolerance, and those who have been on long-term oral opioids. 2. Patients with serious comorbidities such as impaired liver or kidney function, pulmonary dysfunction, or heart failure. 3. Patients with uncontrolled diabetes or hypertension, and those with suspected gastrointestinal obstruction. 4. Patients with abnormal electrocardiogram findings, such as QT interval prolongation >450ms. 5. Patients with a BMI = 30kg/m2, obstructive sleep apnea syndrome, or a STOP-Bang score =3. 6. Patients with a history of severe postoperative nausea and vomiting. 7. Patients with a history of mental illnesses like schizophrenia, preoperative delirium, or communication barriers. 8. Patients deemed lacking the capacity to give informed consent. 9. Other patients deemed unsuitable for participation in the study by the attending physician or clinical supervisor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of moderate to severe pain within 48 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS scores for the patient during rest and activity;The number of PCA pressing times of the patient;Incidence of postoperative adverse reactions in patients;Quality of patient recovery after surgery;Patient satisfaction after surgery;Postoperative sedation of patients;Opioid dosage;Preoperative baseline and intraoperative and postoperative variables;Remedial analgesic dosage; | — |
Countries
China
Contacts
Public ContactYe Zhang
The Second Affliated Hospital of Anhui Medical University
Outcome results
None listed