fungal infection
Conditions
Interventions
Positive group:Central nervous system symptoms after voriconazole use
Negative group:Voriconazole did not cause central nervous symptoms
Sponsors
Xixi Hospital of Hangzhou
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Age =18 years old; 2. Voriconazole was used for the first time and the course of treatment was =7 days; 3. Informed consent to participate in the study and sign the informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1. Patients with existing central nervous system disease before receiving voriconazole; 2. Patients with central nervous system symptoms that may be caused by drug combination; 3. Patients whose metabolism of voriconazole was seriously affected by drug combination; 4. Pregnant or lactating patients; 5. Patients with intellectual and language communication barriers who cannot cooperate with consultation; 6. Patients addicted to smoking, alcohol, coffee and drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| metabonomics;Symptoms of central nervous system toxicity; | — |
Countries
China
Contacts
Public ContactZhou Jing
Xixi Hospital of Hangzhou
Outcome results
None listed