Talaromycosis
Conditions
Interventions
Observation group (Amphotericin B liposome therapy):None
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age = 18 years old; 2. HIV screening test negative; 3. Clinical diagnosis of talaromycosis.
Exclusion criteria
Exclusion criteria: 1. Pregnant women and lactating patients; 2. Severe liver damage (Child Pugh C-grade); 3. Renal dysfunction (creatinine = 5 times the upper limit of normal value) or the need for hemodialysis; 4. Co-infection with other systemic fungal infections (cryptococcosis, candidemia, or fungal infections); 5. Active mycobacterial disease and those currently undergoing chemotherapy; 6. Individuals with mental illness or abnormal behavior; 7. Received systemic antifungal treatment within 48 hours before enrollment; 8. The researcher assessed other factors that were not suitable for inclusion (poor compliance).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical response rate at day 14 after treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| All-cause mortality at day 14;Clinical response rate at week 12;Adverse events within 2 weeks after treatment; | — |
Countries
China
Contacts
Public ContactCunwei Cao
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed