Pulmonary hypertension
Conditions
Interventions
Pulmonary hypertension group:no
Connective tissue disease group without pulmonary hypertension:no
Healthy control group:no
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1)Pulmonary hypertension group 1) Age =18, male or female. 2) From August 2022 to December 2024, he/she was admitted to Beijing Hospital and diagnosed with PH, including CTD-PH, COPD PH and CTEPH, according to the Chinese Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension (2021 edition). 3) The mean pulmonary artery pressure (mPAP) measured by RHC was =25 mmHg (1mmHg= 0.133kPa) after right heart catheterization (RHC) was performed at or before screening and was consistent with diagnosis. 4) Can provide peripheral venous blood samples. 5) Participate in the study voluntarily and sign the informed consent. (2) Connective tissue disease group without pulmonary hypertension 1) Patients diagnosed with SLE or SSc in Beijing Hospital with complete clinical data from August 2022 to December 2024; 2) Gender, age and disease activity were similar to those in CTD-PAH group; 3) Can provide peripheral venous blood samples; 4) Participate in the study voluntarily and sign the informed consent. (3) Healthy control group 1) Healthy subjects matching (approximately) the PH group (gender, age, BMI, ethnicity, etc.); 2) No history of serious cardiovascular, liver, kidney, respiratory, blood, lymphatic, endocrine, immune, mental, nervous, gastrointestinal and other diseases within 3 months before screening; 3) Vital signs, physical examination, laboratory examination, chest X-ray (anterolateral) or CT, 12-lead electrocardiogram, the results show no abnormalities or abnormalities are not clinically significant. Laboratory tests include: blood routine, urine routine, blood biochemistry (liver and kidney function, blood glucose, lipids), virology (hepatitis B virus surface antigen, hepatitis C virus antibodies, human immunodeficiency virus antibodies and syphilis antibodies), blood pregnancy (Women of childbearing age). Laboratory examination (except blood pregnancy test), electrocardiogram, chest film /CT, if there are results of our hospital within 3 months, the screening period will not be tested; 4) Those who can communicate well with the researchers, understand and comply with the requirements of this study, and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1)Pulmonary hypertension group 1) Identify patients with other types of PH. 2) The presence of serious or uncontrolled chronic diseases, such as severe cerebrovascular diseases, malignant tumors, and chronic progressive kidney disease. 3) Pregnant or lactating women, male and female patients planning to give birth during the trial. 4) Participants who are participating in other clinical trials and whose protocol conflicts with the protocol of this study. 5) Other conditions deemed unsuitable for participation in the trial by the investigator. (2) Connective tissue disease group without pulmonary hypertension 1) Patients with suspicious PH clinical symptoms, or UCG indicating PH. (3) Healthy control group 1) Acute disease occurred within two weeks before blood collection; 2) Have undergone major surgical procedures (excluding diagnostic surgical procedures) within 6 months prior to blood collection; 3) Patients who have used drugs for respiratory diseases within 2 weeks before blood collection (except antipyretic and analgesic drugs); 4) Those who received COVID-19 vaccine within 1 week prior to blood collection, or received other vaccines within 4 weeks prior to blood collection, or planned to receive any vaccine during the trial; 5) Participants in other clinical trials within 3 months before blood collection; 6) Those who have donated blood within 3 months before blood collection, and the total blood loss of blood donation or other reasons within 6 months reaches or exceeds 400 mL; 7) Within 1 year before blood collection, drinking more than 14 units of alcohol per week on average (1 unit =360 mL beer or 45mL liquor with 40% alcohol or 150 ml wine), or can not abstain from alcohol within 72 hours before blood collection; 8) Smoking more than 5 cigarettes per day in the 3 months before blood collection; Those who cannot be smoke-free within 72 hours before blood collection. 9) Have a history of drug abuse within 1 year before blood collection; 10) Positive blood pregnancy test; 11) Pregnant or lactating women; 12) According to the judgment of the researcher, there are other circumstances that are not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Six minutes' walk distance ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ultrasonic cardiogram;Right heart catheterization;Electrocardiograph;WHO functional classification of pulmonary hypertension;Lung function in patients with chronic obstructive pulmonary disease and chronic thromboembolic pulmonary hypertension;Plasma NT-proBNP/BNP levels or right atrial pressure; | — |
Countries
China
Contacts
Public ContactAixin Shi
Beijing Hospital
Outcome results
None listed