Mild cognitive impairment
Conditions
Interventions
Sham acupuncture group:Sham acupuncture
Sponsors
Chengdu University of Traditional Chinese Medicine; Affiliated hospital of Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Conforms to the MCI diagnostic criteria (the Jak/Bondi 2014 diagnostic criteria31 in 2014). (2) Aged between 50 and 80 years, right-handed, and Mandarin-speaking. (3) Disease duration exceeding 3 months. (4) Clinical Dementia Rating score of 0.5. (5) Hachinski Ischemic Score less than 4. (6) A minimum of 8 years of education, including vocational and correspondence education, with the ability to understand and complete the assessments. (7) Voluntary participation and signing of an informed consent form. (8) No contraindications for MRI, such as metal implants.
Exclusion criteria
Exclusion criteria: (1) Currently undergoing treatments that interfere with cognitive functions. (2) History of neurological diseases affecting cognitive function (except for early suspected Alzheimer's disease cases). (3) Brain MRI indicative of infection, focal lesions, multiple infarctions, or severe white matter changes (Fazekas score = 3). (4) History of tumors, psychiatric disorders, or severe anxiety (Hamilton anxiety [HAMA] = 29) and depression (Hamilton Depression [HAMD] = 24). (5) Hemorrhagic diseases, bleeding tendencies, or severe skin infections. (6) Severe drug dependency, smoking, drug abuse, or alcoholism. (7) Pregnant, breastfeeding women, or those suspected to be pregnant. (8) Undergone acupuncture or participated in other clinical studies within the last six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer's Disease Assessment Scale - Cognitive; | — |
Secondary
| Measure | Time frame |
|---|---|
| simultaneous EEG-fMRI;Auditory Verbal Learning Test;Shape Trail Test;Boston Naming Test ;The Animal Verbal Fluency Test;The Symbol Digit Modality Test ;the Digit Span Test ;Functional Activities Questionnaire;Hamilton Anxiety Scale;Hamilton Depression Scale;Pittsburgh Sleep Quality Index; | — |
Countries
China
Contacts
Public ContactFanrong Liang
Chengdu University of Traditional Chinese Medicine; Affiliated hospital of Chengdu University of Traditional Chinese Medicine
Outcome results
None listed