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Exploring HMGB1/GSDMD pathway mediating the suicide mechanism of cytotoxic CD4+ T lymphocytes based on protein lactylation modification and the effect of nourishing qi and nourishing yin on AIDS patients

Exploring HMGB1/GSDMD pathway mediating the suicide mechanism of cytotoxic CD4+ T lymphocytes based on protein lactylation modification and the effect of nourishing qi and nourishing yin on AIDS patients

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400084652
Enrollment
Unknown
Registered
2024-05-22
Start date
2024-06-01
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acquired immunodeficiency syndrome

Interventions

Trial group:Taiqi Peiyuan free-decocting granule (15G/time, 2 times/day) + antiretroviral treatment
Trial group:antiretroviral treatment

Sponsors

Fourth Affiliated Hospital of Xinjiang Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1) HIV antibody positive, confirmed by Western Blot; 2) age =18 years old and =60 years old; 3) RRB- syndrome of deficiency of both qi and yin; 4) voluntary and informed consent.

Exclusion criteria

Exclusion criteria: 1) those who took other immunomodulatory or related drugs during the observation period, 2) those who could not tolerate the study, and 3) those who, according to the judgment of the researchers, might interfere with the results of the trial or increase the patients' treatment risk.

Design outcomes

Primary

MeasureTime frame
T cell ;

Secondary

MeasureTime frame
LAMP, LAMP-1, LAMP-2, GZMB;PRF1, NKG7, GNLY;Transcription factors (T-bet, Eomes, Bcl-2);Pyrosis associated proteins (HMGB1, RAGE, NLRP3, casape-1, GSDMD) mRNA;Cytokines HMGB1 and TGF- ß IL-10, IL-1 ß IL-6, TNF- a LT and IL-18;

Countries

China

Contacts

Public ContactJingru Li

Fourth Affiliated Hospital of Xinjiang Medical University

695238046@qq.com+86 159 8177 1593

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026