postoperative cognitive dysfunction
Conditions
Interventions
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Patients 60 to 90 years of age undergoing elective total hip arthroplasty under general anesthesia (2) American Society of Anesthesiologists (ASA) classification I-III
Exclusion criteria
Exclusion criteria: (1) History of communication disorders (e.g., severely impaired speech, hearing, and vision) (2) Use of anti-inflammatory or immunosuppressive drugs (3) Use of antibiotics, probiotics, or gastrointestinal stimulants within 10 days prior to enrollment (4) Cognitive dysfunction (illiterate =17, elementary school =20, secondary school =22, university =23) as assessed by the preoperative Mini-mental State Examination (MMSE) scale (5) Serious organic diseases, such as liver and kidney dysfunction. (6) Presence of other central system diseases, cerebrovascular accidents and history of alcoholism (7) Have a history of diabetes mellitus (8) BMI = 30 (9) Unable to take the neuropsychological test or refused to take it
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analysis of intestinal microbial 16S rRNA sequencing;Fecal metabolomics analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory factors in peripheral blood;Postoperative pain intensity;Postoperative sleep quality;Recovery of gastrointestinal function; | — |
Countries
China
Contacts
Public ContactGao Fang
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed