Patients undergoing thoracic surgery under general anesthesia
Conditions
Interventions
Control group:NA
Sponsors
Renmin Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age =18 years old; 2. To carry out thoracic surgery under elective general anesthesia; 3.ASA score I-II; 4.No history of recent myocardial infarction or cerebral infarction; 5.Voluntary signing of informed consent.
Exclusion criteria
Exclusion criteria: 1.Hormones were used 7 days before surgery, or drugs related to this study were used 48 hours before surgery; 2.Complicated with severe heart, liver, kidney and other important organ lesions; 3.There are patients with cognitive and behavioral deficits, mental system diseases (schizophrenia, mania, bipolar disorder, mental disorder, etc.) and cognitive dysfunction; 4.patients who are known to be allergic to the active ingredients or excipients of esketamine hydrochloride injection or opioids; 5.Pregnancy or lactation patients ; 6.Patients with a history of opioid abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum inflammatory factors;serum cortisol hormone;serum catecholamine; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS pain scores;the time from the end of surgery to the first use of remedial analgesic drugs after surgery ;anesthesia recovery time;the incidence of intraoperative adverse events;the incidence of postoperative adverse events;pharmacoeconomic indicators; | — |
Countries
China
Contacts
Public ContactRong Chen
Renmin Hospital of Wuhan University
Outcome results
None listed