Arthropathy
Conditions
Interventions
LB(Lipid bupivacaine) :Lipid bupivacaine 130mg/20 mL was injected for periarticular injection and adductor canal block respectively
ZB(Levobupivacaine):Levobupivacaine 75 mg/20 mL was injected for periarticular injection and adductor canal block ,respectively
Lipid bupivacaine-levobupivacaine (LZB):Periarticular injection: lipid bupivacaine 130 mg/20 mL, adductor canal block: levobupivacaine 75 mg/20 mL
Sponsors
Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuyying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland)
Eligibility
Sex/Gender
All
Age
60 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. Unilateral (non-revision) knee replacement; 2. Age =60 years old, <80 years old; 3.ASA I-III; 4. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. History of allergic reaction to morphine or local anesthetics; 2. Use analgesics continuously for two weeks or more; 3. History of gastrointestinal ulcer or bleeding; 4. Peripheral neuropathy; 5. Morbid obesity (BMI>40); 6. Platelet count <80*10^9/L; 7. Coagulation dysfunction; 8. Infection at the puncture site; 9. Have a history of mental illness; 10. Thrombus in the lower limbs; 11. Those who are unable to understand the visual analog scale (VAS);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analog Scale (VAS)(at rest and during activity);Self-rating anxiety scale (SAS); | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of analgesic pump compressions and the consumption of analgesic drugs;Early knee range of movement (ROM);Patient satisfaction with analgesia;Additional pain medication use;Saphenous nerve block temperature sensation test;American Knee Society Score (KSS);Visual analog scale (VAS) (during active training); | — |
Countries
China
Contacts
Public ContactJianfeng Ma
The Second Affiliated Hospital and Yuyying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland)
Outcome results
None listed