Perioperative pulmonary function
Conditions
Interventions
Pentoxifylline hydrochloride Group:Valacyclovir hydrochloride 0.5mg was given 10min before anesthesia
Parecoxib sodium group:Parecoxib sodium 40mg was given 10min before anesthesia
Blank control group:Give the same dose of saline 10 min before anesthesia
Combined drug group:Long tocopherol 0.5mg and parecoxib sodium 40mg were given respectively 10min before anesthesia
Sponsors
The Third Hospital of Hebei Medical University;Tiemenguan City People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. ASA classification I-III; 2. Age 40-85 years; 3. Receiving surgical treatment under general anesthesia; 4. Sex is not limited; 5. combined with fragile pulmonary function (moderate or above reduced pulmonary function: preoperative vital capacity (VC) < 80% of the expected value, forced expiratory volume in first second (FEV1) and forced vital capacity (FVC) ratio (FEV1%) < 70%; blood gas analysis indexes capacity (FVC) ratio (FEV1%) < 70%; blood gas analysis index (60mmHG < oxygen partial pressure < 75mmHG); patients with combined moderate or higher chronic obstructive pulmonary disease; combined chronic lung diseases such as pneumonic pneumonia, bronchial asthma, bronchiectasis, lung cancer, chronic obstructive pulmonary emphysema or pulmonary alveoli; 6. Voluntary participation and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who refused to be enrolled in this study; 2. Patients who have met the criteria for respiratory failure before surgery; 3. Patients with severe peptic ulcers, hematologic disorders; 4. Patients with severe abnormalities of cardiopulmonary, hepatic and renal functions, and severe hypertension; 5. Patients with a history of allergy to anticholinergic drugs or NSAIDs, a history of aspirin asthma and those who have taken NSAIDs 1 week before surgery; 6. Patients with intraoperative circulatory as well as organ function instability due to bleeding, allergy, etc., who need to be sent to ICU with a tube after surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood gas analysis results;CRP; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pulse Oxygen;Extubation time;Airway pressure;PACU time;Delayed extraction;Returned to ICU after surgery; | — |
Countries
China
Contacts
Public ContactLiuPeng
The Third Hospital of Hebei Medical University/Tiemenguan City People's Hospital
Outcome results
None listed