Effect of different vasoactive drugs combined with restrictive infusion on oxygenation status in one-lung ventilated patients

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400084583

Enrollment

Unknown

Registered

2024-05-21

Start date

2024-05-23

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oxygenation

Interventions

noradrenaline group:Intravenous infusion of noradrenaline 0.03 ug/kg/min during surgery

phenylephrine group:Intravenous infusion of phenylephrine 0.3 ug/kg/min during surgery

blank group:Push into 3~6mg of ephedrine intermittently

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: ? Patients undergoing elective thoracoscopic OLV under general anesthesia at our hospital. ? ASA grade?-?. ? Intraoperative OLV duration was at least 60min ? Patients with normal cardiac, hepatic and renal functions before surgery. ? Informed consent form was obtained.

Exclusion criteria

Exclusion criteria: ? patients refused. ? Patients with severe (hypoxemia SpO 2 or PaO 2 <50mmHg) during OLV. ? Preoperative rescue medical history ? Major complications occurred during and after surgery.

Design outcomes

Primary

Measure	Time frame
endothelin;cox-2;DO2;VO2;ERO2;A-aDO2;Qs/Qt;	—

Secondary

Measure	Time frame
Heart rate;Mean arterial pressure;SpO2;	—

Countries

China

Contacts

Public ContactYongzhe Liu

The Third Medical Center of Chinese PLA General Hospital

lyzgao@qq.com+86 158 1133 1366

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026