acute tympanic membrane perforation
Conditions
Interventions
First stage-Normal saline treatment group:0.9% saline was administered by ear drops through the external ear canal and applied locally to the surface of the tympanic membrane, twice a day, 2 drops per
First stage-control group:Follow-up observation, no treatment.
Second stage-Ofloxacin ear drops treatment group:Ofloxacin ear drop was administered by ear drops through the external ear canal and applied locally to the surface of the tympanic membrane, twice a da
Second stage-Recombinant bovine basic fibroblast growth factor eye drops treatment group:Recombinant bovine basic fibroblast growth factor eye drops (specification: 21000IU/5ml/ bottle) was administer
Second stage-Normal saline treatment group:0.9% saline was administered by ear drops through the external ear canal and applied locally to the surface of the tympanic membrane, twice a day, 2 drops pe
Sponsors
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
16 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age greater than 16 years old; 2. Tympanic membrane perforation larger than 1/4 of the area of the pars tensa; 3. Perforation duration less than 72 hours; 4. Air-bone gap <30 dB.
Exclusion criteria
Exclusion criteria: 1. Middle ear infection; 2. Granulation tissue proliferation in the middle ear; 3. Damage to the ossicular chain; 4. Sensorineural hearing loss caused by trauma-induced tympanic membrane perforation; 5. Individuals with Eustachian tube dysfunction; 6. Special populations such as pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The healing of the eardrum; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hearing improvement; | — |
Countries
China
Contacts
Public ContactZhengnong Chen
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed