intrapulmonary shunt
Conditions
Interventions
Esketamine group (group SK):Esketamine 0.25mg/kg was injected intravenously before incision, and 0.15mg/(kg?h) was pumped continuously during the operation until ventilation was restored in both lungs
Conventional group (group C):Equal dose of normal saline was injected intravenously before incision. During the operation, 0.15mg/(kg?h) was continuously pumped until ventilation was restored in both
Sponsors
Ningxia Medical University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Patients aged 18-65 years old, regardless of gender; (2) No significant abnormality was found in preoperative pulmonary function measurement; (3) The Body Mass Index (BMI) of patients should be between 18.5-23.9kg/m^2; (4)ASA Class I-III; (5) There were no obvious abnormalities in cardiac, brain, liver and renal function before operation; (6) The operation time is expected to be 1h~3h.
Exclusion criteria
Exclusion criteria: (1) Allergic to esketamine; (2) Patients with mental diseases; (3) Patients with hypertension, coronary heart disease, pulmonary hypertension, intraocular pressure and intracranial hypertension; (4) Patients with a family history of malignant hyperthermia or a high risk of malignant hyperthermia (such as strabismus, scoliosis, etc.); (5) Previous history of thoracotomy surgery; (6) The patient had hypoxemia before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intrapulmonary shunt ;oxygenation index; | — |
Secondary
| Measure | Time frame |
|---|---|
| usage of Remifentanil;usage of propofol;Oxygen partial pressure difference;oxygenation pressure; | — |
Countries
China
Contacts
Public ContactMin Hongxin
Ningxia Medical University General Hospital
Outcome results
None listed