Chronic cough associated with idiopathic pulmonary fibrosis
Conditions
Interventions
Treatment group:Lianfei Zhike prescription, 1 dose a day, divided into 2 times. The course of treatment is 28 days, with continuous medication.
Control group:Lianfei Zhike formula granule simulation, 1 dose per day, divided into 2 times. The course of treatment is 28 days, with continuous medication.
Sponsors
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Western medicine diagnosed IPF, and cough as the main clinical manifestations; (2) TCM syndrome differentiation for lung and kidney qi deficiency, syndrome of dissipation and loss; (3) Age 40-75 years old; (4) The lung function of the vital capacity (VC) is greater than 30% of the estimated value, while the lung carbon monoxide dispersion (DLCO) is greater than 30% of the estimated value; (5) Did not participate in other clinical researchers in the past 1 month; (6) Those who voluntarily accept clinical trials and sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Exclude chronic cough caused by other factors, such as cough variant asthma, chronic bronchitis, bronchiectasis, chronic obstructive pulmonary disease, postnasal drip syndrome, gastroesophageal reflux cough, eosinophilic bronchitis, allergic cough, and use of angiotensin-converting enzyme inhibitors; (2) The absolute and relative contraindications of the 6-minute walking test were excluded, including uncontrolled acute coronary syndrome, acute heart failure, acute pulmonary embolism and pulmonary infarction, acute respiratory failure, acute infectious diseases, mental dysfunction, peripheral SpO<85% at rest, and walking dysfunction; (3) Allergic constitution or allergic to the experimental drug; (4) Patients with severe cardiovascular and cerebrovascular diseases, abnormal liver function or abnormal kidney function; (5) Patients with malignant tumor, blood system disease and mental illness; (6) Women who are pregnant or breastfeeding; (7) Other conditions deemed unsuitable by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cough visual analogue score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Leicester cough Quality of Life Scale;TCM syndrome score;Percutaneous arterial oxygen saturation;Lung function (VC, VC%pred, DLCO, DLCO%pred), exhaled nitric oxide (FeNO);6 minutes walking test; | — |
Countries
China
Contacts
Public ContactMiao qing
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Outcome results
None listed