Multi-drug resistant bacterial infections
Conditions
Interventions
Sponsors
Shanghai Donglei Brain Hospital
Eligibility
Sex/Gender
All
Age
14 Years to 120 Years
Inclusion criteria
Inclusion criteria: 1. Patients over 14 years of age with multi-drug resistant bacterial infections; 2. The pathogenic bacteria infecting the patient should meet one of the following conditions: (1) The pathogenic bacteria are fully resistant to antibiotics; (2) Pathogenic bacteria are resistant to key antibiotics (see WHO's 2017 publication of 12 classes of superbugs ); (3) Pathogenic bacteria are sensitive to key antibiotics in vitro but this antibiotic treatment is ineffective or ineffective (ineffective or ineffective antibiotic treatment is defined as the patient's failure to achieve clearance of pathogenic bacteria/improvement in clinical symptoms after 2 courses (14 days) of treatment with sensitive antibiotics); (4) Pathogenic bacteria limited to the use of key sensitive antibiotics (e.g. organ toxicity or patients allergic to this antibiotic); 3. Ability to screen for at least one lytic phage; 4. Ability to administer the drug by spraying, topical application, nebulized inhalation, perfusion, local injection or catheter at the site of infection; 5. Subjects and family members (or guardians) fully read, understand and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Bacterial infection can be effectively controlled by antibiotic therapy; 2. No other route of administration other than intravenous administration; 3. Patients who are judged by the investigator to be unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The target strain was completely cleared or the load decreased without clinical symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Significant improvement of clinical symptoms; | — |
Countries
China
Contacts
Public ContactZhuying Cai
Shanghai Donglei Brain Hospital
Outcome results
None listed