knee osteoarthritis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for KOA formulated in the "Guidelines for the Diagnosis and Treatment of Osteoarthritis" of the Joint Surgery Group of the Chinese Academy of Osteology in 2018; 2. Age =45 years and =75 years, BMI > 19 kg/m² and <30kg/m²; No gender limitation; 3.K/L grade =1 and =3; 4. Simple Mental State Examination Scale (MMSE) =24 points; 5. Willing to sign informed consent and participate in this study voluntarily.
Exclusion criteria
Exclusion criteria: 1. Falls twice or more within six months; 2. A history of knee surgery (such as arthroscopic surgery) within six months or intra-articular corticosteroid injection within three months; 3. Knee pain is associated with rheumatic diseases or caused by inflammation; 4. Have primary or secondary muscle diseases (such as idiopathic inflammatory myopathy, progressive muscular dystrophy, etc.); 5. Severe internal and valgus deformity of knee joint; 6. Severe trauma of knee joint or fracture of lower limb resulting in instability of lower limb joint; 7. Patients with serious cardiovascular and cerebrovascular diseases, musculoskeletal system diseases and other contraindications to exercise (YNMT)·
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total WOMACA Scale score (including pain, stiffness, function of daily activities); | — |
Secondary
| Measure | Time frame |
|---|---|
| Bilateral knee range of motion (flexion and extension Angle);Time up to go ;Proprioceptive test (30°, 45°, 60° position sense assessment);Isokinetic muscle force test (peak moment, total work done, peak moment ratio of active muscle to antagonist muscle);Pro-kin dynamic and static balance test (stability limit ratio, moving track area, moving track length);Lower extremity surface electromyography (integrated EMG of rectus femoris, medial and lateral femoris muscles, median frequency, muscle contribution rate, median frequency difference rate, root mean square value);fNIRS;BBS; | — |
Countries
China
Contacts
Yueyang Hospital of Integrated traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine