Postoperative analgesia after caesarean section
Conditions
Interventions
Hydromorphone group:Mothers in the hydromorphone group were given an initial epidural dose of 400 ug. When the first woman had good analgesia, a biased coin up/down sequential number was drawn, and th
there was an 8/9 chance that she would be assigned to the group where the dose was kept constant. If maternal analgesia is inadequate, the next higher dose of drug is selected for push. Each dose vari
Morphine group:Mothers in the morphine group were given an initial epidural dose of 2000 ug. When the first woman had good analgesia, a biased coin up/down sequential number was drawn, and there was a
Sponsors
Sichuan Academy of Medical Sciences.Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Cesarean section mothers who are willing to participate in the trial. 2. ASA class I ~ III. 3. Full-term pregnant primigravida (>37 weeks)
Exclusion criteria
Exclusion criteria: 1. Contraindications to combined spinal-epidural anesthesia 2. Allergy to opioids. 3. History of analgesic abuse. 4. Cesarean section operation and other operations (tubal ligation, fibroid removal, etc.). 5. History of nausea and vomiting. 6. History of itching. 7. Change of anaesthesia during the operation 8. Multiple pregnancies and multiple caesarean sections. 9. BMI=40 kg/m^2
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hydromorphone ED90;Morphine ED90; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS scores at 6, 12, and 24 hours postsurgery;Satisfaction with analgesia;Total postoperative opioid consumption;Nausea and vomiting;itching; | — |
Countries
China
Contacts
Public ContactMin Xie
Sichuan Academy of Medical Sciences. Sichuan Provincial People’s Hospital
Outcome results
None listed