hand-foot skin reactions
Conditions
Interventions
Control group:Use Urea Ointment
Sponsors
Jiangsu Province Hospital on Integration of Chinese and Western Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Malignant tumors confirmed by pathology; 2. Hand-foot skin reaction occurs, and its appearance is obviously related to targeted drug (such as anlotinib, fruquintinib, regorafenib, capecitabine, etc.); 3. KPS score > 60 points; 4. Age 18-85 years old, gender is not limited, expected survival period >= 3 months; 5. Individuals without strict center of gravity, liver, kidney, or hematopoietic system damage; 6. Clear consciousness, ability to judge and evaluate one's own pain, have high treatment compliance; 7. Patients with no local skin allergies or other skin diseases in their hands or feet before treatment; 8.Subject and family members are informed and sign consent forms
Exclusion criteria
Exclusion criteria: 1. Those who do not meet the inclusion criteria mentioned above; 2.The clinical judgment of hand and foot skin reactions is not related to targeted drugs, such as those caused by chemotherapy drugs; 3.Symptoms of nerve compression due to advanced malignant tumors causing brain or limb metastasis or severe cervical spondylosis; Patients with nervous system diseases caused by immune system diseases, severe infections, severe diabetes, etc; 4. Pregnant women and lactating women; 5. Participants in other similar research projects on hand and foot skin reactions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HFSR classification; | — |
Secondary
| Measure | Time frame |
|---|---|
| HFSR Specific Quality of Life Scale (HFS-14);HFSR Common Symptom Scale;Pain score;Completion rate of anti-tumor drugs;Toxic side effect assessmen;Clinical remission rate;Pain relief rate; | — |
Countries
China
Contacts
Public ContactHuo Jiege
Jiangsu Province Hospital on Integration of Chinese and Western Medicine
Outcome results
None listed