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Efficacy and rehabilitation mechanism of low-frequency rTMS combined with music therapy in the treatment of non-fluent aphasia during stroke recovery period

Efficacy and rehabilitation mechanism of low-frequency rTMS combined with music therapy in the treatment of non-fluent aphasia during stroke recovery period

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400084441
Enrollment
Unknown
Registered
2024-05-16
Start date
2022-06-06
Completion date
Unknown
Last updated
2024-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non fluent aphasia during convalescence of stroke

Interventions

Low frequency rTMS group:Low-frequency rTMS therapy was performed first, followed by speech training.
music therapy group:Music therapy followed by speech training.
Joint group:Music therapy was performed first, followed by low-frequency rTMS therapy, and finally speech training.

Sponsors

Zhejiang Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
12 Years to 85 Years

Inclusion criteria

Inclusion criteria: ?The diagnostic criteria for stroke conform to the "China Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2014", and it was confirmed as a single lesion in the left cerebral hemisphere by head CT or MRI; ?The first onset, the course of the disease is 1 to 3 months, and there is no language dysfunction before the onset; ? Clear consciousness and able to cooperate with treatment; ? Non-fluent aphasia was diagnosed by the score of the Western Aphasia Battery (WAB). Speech fluency 0-4 points, aphasia quotient (AQ) <93.8; ? The native language is Chinese; ? Education level above primary school; ? Sign the informed consent.

Exclusion criteria

Exclusion criteria: ? Non-fluent aphasia not caused by cerebral infarction or cerebral hemorrhage; ? Fluency aphasia; ? Patients with skull defect after craniotomy; ?There are any metal foreign objects or electronic devices in the body; ? Patients with epilepsy; ? Visual or hearing impairment, unable to complete the evaluation and treatment of language function.

Design outcomes

Primary

MeasureTime frame
western aphasia battery;Boston Diagnostic Aphasia Examination;stroke aphasic depression questionnaire hospital version;

Secondary

MeasureTime frame
Resting functional magnetic resonance imaging;Diffusion tensor image;

Countries

China

Contacts

Public ContactLiya Zhang

Zhejiang Provincial People's Hospital

zhangliyahz@163.com+86 135 8828 1056

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026