Down Syndrome
Conditions
Interventions
Control Group:None
Trisomy 21 Group:None
Sponsors
Department of Obstetrics and Gynecology, Women's Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to 46 Years
Inclusion criteria
Inclusion criteria: Trisomy 21 Group: 1) Patient age is =18 years old; 2) The aborted fetus gestational week is 17-23 weeks; 3) The embryos in the disease group should be diagnosed with Trisomy 21 through means like amniocentesis, noninvasive prenatal diagnosis, and have proof of pregnancy termination; 4) Both the patient and their spouse have no family history; 5) Complete medical records are required from artificial or pharmaceutical abortion surgery conducted at the Obstetrics and Gynecology Hospital affiliated with Zhejiang University School of Medicine; 6) The patients should sign an informed consent form after fully understanding the purpose of the donation, potential risks, and benefits. Control Group: 1) Patient age is =18 years old; 2) The aborted fetus gestational week is 17-23 weeks; 3) The control group embryos should have no obvious abnormalities discovered during the pregnancy process, no Trisomy 21 genetic diseases in prenatal screening, and pregnancy has to be terminated due to premature rupture of membranes, cervical shortening, or other medical reasons; 4) Both patient and their spouse have no family history; 5) Complete medical records are required from artificial or pharmaceutical abortion surgery conducted at the Obstetrics and Gynecology Hospital affiliated with Zhejiang University School of Medicine; 6) The patient should sign an informed consent form after fully understanding the purpose of the donation, potential risks, and benefits.
Exclusion criteria
Exclusion criteria: 1) The chromosomal karyotype of the embryo is normal and the gestational age is greater than 22 weeks (which does not conform to international ethical standards); 2) The known embryo combined with other monogenic, polygenic or chromosomal genetic diseases besides the target disease; 3) The patient was exposed to toxic substances or harmful environmental influences during pregnancy; The patient has endocrine disorder (thyroid function, pancreatic function; corpus luteum function).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Single-cell transcriptome analysis; | — |
Countries
China
Contacts
Public ContactJiang Ruoan
Department of Obstetrics and Gynecology, Women's Hospital, Zhejiang University School of Medicine
Outcome results
None listed