Clinical observation of Duhuo Jisheng decoction in the prevention and treatment of intervertebral disc herniation with liver and kidney deficiency based on serum metabonomics and quantitative MRI

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400084420

Enrollment

Unknown

Registered

2024-05-16

Start date

2024-06-01

Completion date

Unknown

Last updated

2024-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

protrusion of lumbar intervertebral disc

Interventions

Conventional treatment group:Conventional treatment

Duhuo Jisheng decoction + conventional treatment group:Conventional treatment + Duhuo Jisheng decoction

normal group:Normal people were recruited and no intervention was carried out.

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: ? Patients who met the diagnostic criteria of LDH; ? Conforming to the TCM syndrome diagnostic criteria; ? aged 18-80 years old; ? the symptoms correspond to the imaging examination; ? no recent use of painkillers, liver and kidney tonic Chinese medicine compound or Chinese patent medicine, no systematic treatment; ? voluntarily participate in this study and sign the informed consent.

Exclusion criteria

Exclusion criteria: ? Patients who did not meet the diagnostic criteria and inclusion criteria of lumbar disc herniation; ? caused by diseases such as spinal stenosis, vertebral tumor or tuberculosis; ? patients with lumbar spondylolisthesis, lumbar fracture, lumbar tuberculosis and bone tumor; ? people who are susceptible to allergy; (5) previous history of lumbar surgery; ? lower limb muscle weakness and neurogenic claudication; ? Severe diseases of cardiovascular system, liver, kidney, hematopoietic system, mental patients, pregnant women; Participating in other clinical investigators; ? huge herniated or prolapsed intervertebral disc with definite surgical indications; ? Cauda equina syndrome, obvious neurological impairment, especially secondary defecation dysfunction.

Design outcomes

Primary

Measure	Time frame
Chinese medicine symptom complex score;Oswestry Disability Index;Japanese Orthopaedic Association Low Back Pain Score;Simplified McGill Pain Scale;World Health Organization Quality of Life questionnaire-short form;	—

Secondary

Measure	Time frame
age;Duration of disease;height;weight;IL-1ß;TNF-a;erythrocyte sedimentation rate;High sensitive C-reactive protein;Quantitative magnetic resonance imaging data;	—

Countries

china

Contacts

Public ContactZENG JING QI

The Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine

846484577@qq.com+86 139 7313 7130

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026